Floxal eye ointment 0,3% 3 gr #1

Floxal eye ointment 0,3% 3 gr #1
Manufactured by: Germany
Product Code: 7564
$11.80

Qty:  BUY
You can buy Floxal eye ointment 0,3% 3 gr #1 here.

 

Pharmacodynamics
 
Fluoroquinolone antibiotic broad-spectrum. Has a bactericidal effect. Affects the bacterial enzyme DNA gidrazu providing sverhspirilizatsiyu and thus the stability of DNA of bacteria. Drug destabilizes the DNA chain, resulting in the death of the bacteria. It is active against organisms producing beta-lactamases. To the drug sensitive: Staphylococcus aureus, Staphylococcus epidermidis, Neisseria gonorrhoeae, Neisseria meningitis, E. coli, Citrobacter, Klebsiella, enterobacteria, Hafnia, Proteus (indole-positive and indole-negative), Salmonella, Shigella, Yersinis enterocolitica, Campilobacter jejuni, Aeromonas Plesiomonas , Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, chlamydia, legionella. Different sensitivity to the drug have: enterococci, Streptococcus pyogenes, pneumoniae and viridans, Serrratio marcescens, Pseudomonas aeruginosa, Acinetobacter, Mycoplasma hominis and pneumoniae, Mycobacterium tuberculosis, and Mycobacterium fortuim. In most cases, insensitive: Ureaplasmaurealyticum, Nocardia asteroides, anaerobic bacteria (eg, Bacteroides spp., Peptokokki, peptostreptokokki, Eubacterium spp., Fusobacterium spp., Clostridium difficile). No effect on Treponema pallidum.
 
Pharmacokinetics
 
Rapidly and completely absorbed following oral administration. Bioavailability of over 95%, the relationship with proteins: 6-10%, while the maximum concentration at the onset of oral: 30-60 min, half-life 7.6 h, excreted by the kidneys by 75-90% (unchanged), the distribution of leather , soft tissue, bone, and organs of the abdomen and pelvis, respiratory system, well penetrates the blood-brain barrier and the placenta is secreted in human milk. Metabolized by about 5% of the drug in the liver.
 
Statement
 
The diseases caused by microorganisms sensitive to ofloxacin: respiratory infections, ear, nose, throat, skin, soft tissues, bones, joints, infectious and inflammatory diseases of the abdominal organs (except bacterial enteritis), kidney, urinary tract, pelvic genital gonorrhea.
 
Dosing regimen
 
Intravenous administration: Urinary tract infections - 100 mg 1-2 times / day, an infection of the kidneys and reproductive organs - 100 mg 2 times / day to 200 mg 2 times / day, respiratory tract infections, as well as the throat, ear and nose infections skin and soft tissue, bone and joint infections, abdominal infections, bacterial enteritis, septic infections - 200 mg 2 times / day. In individual cases, when the bacteria with different sensitivities, severe infections (eg, respiratory tract, bones and joints), infections with associated complicating factors, as well as the lack of sensitivity of microorganisms to the drug may need to increase the dose to 400 mg 2 times / day. Patients with clearly reduced the protective capacity of the body to prevent infections should be administered 400-600 mg ofloxacin daily. Infusion duration of 30 minutes. Should be used only as svezhevskrytogo solution in a vial. Assignment inside: for adults is 200 mg to 800 mg per day. 400 mg can be administered as a single daily dose, preferably in the morning. If necessary, the dose may be increased up to 600-800 mg / day in two single doses. Dosage in renal impairment defined by creatinine clearance: creatinine clearance 20 to 50 mL / min is prescribed an initial dose equal to 0.2 g, followed by 0.1 g every 24 h creatinine clearance less than 20 ml / min 100 mg every 24 hours hemodialysis and peritoneal dialysis - po100 mg every 24 hours maximum daily dose with reduced liver function should not exceed 400 mg / day. Duration of treatment is determined to be susceptible to the drug and the clinical picture. Treatment should continue for at least 3 days after the disappearance of symptoms and complete normalization of temperature. In most cases, acute infections, treatment is 7-10 days. In the treatment of salmonellosis treatment is 7-8 days for uncomplicated lower urinary tract infections treated in an average of 3-5 days.
 
Side effects
 
Occur in 3-4% of cases. Effects on the gastrointestinal tract: gastralgia, anorexia, nausea, vomiting, diarrhea. Severe or stop diarrhea during or within the first weeks of treatment floksatsinom may indicate pseudomembranous colitis. In such cases, ofloxacin should be terminated immediately. In this case, contraindicated drugs that inhibit peristalsis. The nervous system: headache, dizziness, lack of movement and tremors, seizures, convulsions, numbness and paresthesias in the limbs, impaired vision: double vision and color vision, disturbances of taste, smell, hearing and balance, intense dreams up to nightmares, psychotic reactions, anxiety, state of excitement, anxiety, depression, confusion, hallucinations. These reactions occur in part after the first dose. The action on the circulatory system: blood pressure during the infusion temporarily reduced, with a sharp decrease in blood pressure injection should be discontinued. Allergic reactions: skin reactions such as skin rash (in rare cases, a bubble), pruritus, rarely observed skin reactions associated with strong exposure to sunlight (photosensitivity), erythema multiforme, pinpoint hemorrhages (petechiae), blister formation with bleeding (hemorrhagic blisters ) and small nodules / papules) with crust showing lesions of blood vessels (vasculitis), allergic inflammation of the lungs (pneumonitis), allergic inflammation of the kidneys (interstitial nephritis), eosinophilia, fever, swelling of the face and throat, choking. In such cases, the drug should be lifted immediately. Hematologic reactions: leukopenia, agranulocytosis, anemia, thrombocytopenia, pancytopenia, hemolytic anemia. Of the liver: elevated liver enzymes and serum bilirubin, jaundice due to reduced allocation of bilirubin (cholestatic jaundice). The kidneys: renal failure azotovydelitelnoy or interstitial nephritis. All the side effects usually disappear after drug withdrawal.
 
Contraindications
 
Hypersensitivity to ofloxacin or other fluoroquinolones (quinolone derivative acid), a history of epilepsy, central nervous system (CNS) with a reduced seizure threshold (eg, traumatic brain injury, stroke or inflammatory processes in the CNS). Childhood and adolescence is not completed skeletal growth., Pregnancy and lactation.
 
Interaction
 
Miscible and compatible with the following infusion solutions: isotonic saline, Ringer's solution, 5% solution of fructose, 5% glucose solution. Simultaneous treatment with antacids containing aluminum hydroxide or magnesium can cause a decrease in absorption of ofloxacin, so the time interval between these agents must be at least 4 hours Decreases theophylline clearance by 25%, so while the application should reduce the dose of theophylline. Co-administration with drugs that have the potential ability to lower blood pressure, it can cause a sharp decline. Therefore, in such cases, and while the introduction barbituratsoderzhaschih, anesthetics should monitor heart rate, blood pressure, ECG. There have been cases when the administration of fluoroquinolones with other drugs that reduce the seizure threshold (eg, theophylline), led to a marked reduction in seizure threshold in the brain.
 
Cautions
 
The drug is not recommended for more than 2 months. Patients are not recommended to expose themselves without sunlight, avoiding irradiation with ultraviolet rays (mercury-quartz lamp, solarium). The drug can impair the speed of psychomotor reactions, so you should refrain from driving. With care prescribe the drug to patients with cerebral arteriosclerosis, cerebral circulatory disorders, impaired renal function. Using the drug is not recommended for women to use tampons "Tampax" due to the risk of developing thrush.
 

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