Ampicillinum trihydras tablets 250 mg #20

Ampicillinum trihydras tablets 250 mg #20
Manufactured by: Russia / Ukraine
Product Code: 22416

Qty:  BUY
You can buy Ampicillinum trihydras tablets 250 mg #20 here.


Mode of action
Broad-spectrum antibiotic of the group of semi-synthetic penicillins. Bactericidal effect by inhibiting the synthesis of bacterial cell wall. It is active against gram-positive bacteria: cocci - Staphylococcus spp. (With the exception of strains producing penicillinase), Streptococcus spp. (Including Enterococcus); aerobic asporogenous bacteria - Listeria monocytogenes. Ampicillin is also active against gram-negative microorganisms: aerobic - Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Bordetella pertussis, some strains of Haemophilus influenzae. Ampicillin is destroyed by penicillinase. Acid-resistant.
After oral administration, is well absorbed from the gastrointestinal tract. Ampicillin is distributed in most organs and tissues. Crosses the placenta, does not penetrate the BBB. When inflammation of the meninges BBB permeability increases dramatically. 30% of ampicillin is metabolized in the liver. Excreted in the urine and bile.
Infectious-inflammatory diseases caused by microorganisms sensitive to ampicillin: including infections of the ear, nose and throat, odontogenic infection, bronchopulmonary infection, acute and chronic urinary tract infections, gastrointestinal infections (including Salmonella, cholecystitis), gynecological infections, meningitis, endocarditis, septicemia, sepsis, rheumatic fever, erysipelas, scarlet fever, infections of skin and soft tissues.
Dosage and administration
Set individually depending on the severity, localization of infection and sensitivity.
When administered to adult single dose of 250-500 mg, the multiplicity of reception - 4 times / day. Children weighing 20 kg each appoint 12.5-25 mg / kg every 6 hours
For V / m, in / in a single dose for adults is 250-500 mg every 4-6 hours for children single dose of 25-50 mg / kg.
Duration of treatment depends on the localization of infection and the characteristics of the disease.
Maximum dose: adult daily dose for oral administration - 4 g daily dose of I / and / m, the introduction of -14
Side effect
Allergic reactions: urticaria, erythema, angioedema, rhinitis, conjunctivitis, rarely - fever, joint pain, eosinophilia, very rarely - anaphylactic shock.
Part of the digestive system: nausea, vomiting, intestinal dysbiosis, colitis caused by C.difficale.
Effects caused by chemotherapeutic action: oral candidiasis, vaginal candidiasis.
Increased sensitivity to ampicillin and other penicillins, abnormal liver function.
Pregnancy and lactation
Perhaps the use of ampicillin during pregnancy may be needed. Ampicillin is excreted in breast milk in low concentrations. If necessary, ampicillin use during lactation should decide on the termination of breastfeeding.
In the treatment of ampicillin requires systematic monitoring of renal function, liver and peripheral blood. Patients with impaired renal function requires dosing adjustment in accordance with the values ​​of QA.
At high doses in patients with renal insufficiency may toxic effects on the CNS.
In the application of ampicillin in patients with bacteremia (sepsis) can bacteriolysis reaction (Jarisch-Herxheimer reaction).
Ampicillin in the form of tablets, capsules and powder for injection is included in the list of VED.
Drug Interactions
Probenecid while the use of ampicillin decreases the tubular secretion of the latter, resulting in increased concentrations of ampicillin in plasma and increases the risk of toxic effects.
With the simultaneous use of ampicillin with oral medications estrogensoderzhimi a decline of their effectiveness, probably due to attenuation of hepatic circulation of estrogens.

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