Clostilbegyt 50mg #10

Clostilbegyt 50mg #10
Manufactured by: EGIS
Product Code: 438

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You can buy Clostilbegyt 50mg #10 here.

Pharmacological properties

Antiestrogens. Selectively blocking the binding of estradiol receptors in the hypothalamus and the ovaries, stimulates ovulation by negative feedback inhibition, and increased production of gonadotropins (FSH, LH, prolactin).PharmacokineticsWell absorbed from the gastrointestinal tract. It is metabolized in the liver. T1 / 2 - 5-7 days. 37-51% is excreted in the feces of clomiphene, a small amount (including in the form of metabolites) is excreted in the urine.Indications for useStimulation of ovulation in anovulatory cycles, the treatment of disorders of ovulation with hypothalamic insufficiency, secondary amenorrhea of ​​different etiologies, oligomenorrhea, dysfunctional uterine bleeding, galactorrhea (with the exception of tumor genesis), a syndrome of Stein - Leventhal syndrome, Chiari - Frommelya, oligospermia. Pregnancy and Lactation: Contraindicated in pregnancy.

Dosage and administration

Prior to and during treatment (permanent) should be thorough gynecological examination. Treatment is effective for normal or reduced level of total urinary gonadotropins, unchanged (palpation) the status of the ovaries, as well as the 'corrected the thyroid and adrenal glands. In the absence of ovulation prior to treatment is necessary to eliminate other causes of infertility or to appropriate treatment. With an increase in ovarian cystic transformation or suspend treatment until normalization of their size. Continue therapy with the use of minimal doses, or shorten the treatment period. Because of the difficulty in determining the time of ovulation and corpus luteum insufficiency after treatment is recommended prophylactic administration of progesterone. It is recommended to monitor liver function. Should not be used during the drivers of vehicles and people skills are related to increased concentration.Dosage and administration:Inside, with regular menstruation, treatment begins on day 5 of the cycle. The first course - 50 mg / day for 5 days (ovulation usually occurs between 11 and 15 days of the cycle). In the absence of ovulation, a second course - 100 mg / day for 5 days, if necessary - the third. In the absence of effect after a 3-month break there is another three-month course. The maximum dose for one year - less than 750 mg. When amenorrhea occurring after discontinuation of contraceptive pills - 50 mg / day for 5 days. In oligospermia - 50 mg 1-2 times a day for 6 weeks (under systematic control of semen).Side effectsThe nervous system and sense organs: headache, dizziness, depression, fatigue, anxiety, insomnia, blurred vision (held after cessation of treatment).From the digestive tract: nausea, vomiting.Since the genitourinary system: increase in cystic ovaries, dysmenorrhea, pollakiuria, polyuria, multiple pregnancy.Allergic reactions: seldom - urticaria, allergic dermatitis.Others: hot flashes, weight gain, pain in the abdomen, the chest, testicles, hyperthermia, reversible hair loss.ContraindicationsHypersensitivity to the drug, hepatic dysfunction, ovarian cysts, malignant neoplasm of genital organs, primary hypofunction of the pituitary, uterine bleeding of unknown etiology, pregnancy (including suspicion of it).Interaction with other medicinal products

Data on drug interactions drug Clomid is not available.

OverdoseSymptoms include nausea, vomiting, flushing, blurred vision, pain in the abdomen.

Treatment: symptomatic therapy.Features of the applicationThe drug is appropriate to assign to cases where the total content of gonadotropins in the urine or slightly below the normal range, organic changes in the ovaries is not detected, the functional state of the thyroid and adrenal glands were normal.In the course of drug treatment should be continued monitoring gynecologist should check the function of the ovaries, perform vaginal examination, including monitor symptom pupil.In the appointment of Clomid to induce ovulation of its clinical effect (ie the occurrence of ovulation) is determined by the presence of biphasic basal body temperature, an average increase of cyclic products LH, increased levels of serum progesterone during the luteal phase of the likely average or menstrual bleeding in women with amenorrhea. If, after ovulation took place probably has not followed the menstrual bleeding, should take into account the possibility of pregnancy and before the next course of treatment it should be deleted.The appearance of signs of ovarian hyperstimulation and other adverse effects require dose reduction or discontinuation of the drug. Taking place in the process of taking Clomid vasomotor symptoms, as well as violations of cease after completion of treatment.Rational Combination Therapy is carried out according to indications, using drugs Clomid and gonadotropins. Monitoring of laboratory parameters prior to treatment Clomid is recommended to assess liver function.Effects on ability to drive and control mechanismsIt should not be prescribed the drug outpatient individuals whose work requires quickness of psychomotor reactions.

Terms and Conditions of storage.

When temperature is 15-25 ° C Shelf life: 5 years

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