Amoksiklav (Amoxiclav) powder 156.25 mg / 5 ml vial. 25 g, to prepare 100 ml of susp.

You can buy Amoksiklav (Amoxiclav) powder 156.25 mg / 5 ml vial. 25 g, to prepare 100 ml of susp. here.


Mode of action:
Amoxiclav - antibacterial combination product. Active ingredients: amoxicillin - an antibiotic of the penicillin group of broad-spectrum and inhibitor of beta-lactamase microorganisms - clavulanic acid. Clavulanic acid prevents the destruction of amoxicillin by the formation of stable complexes with beta-lactamases: the complexes with the inactive and stable.
Amoxicillin is effective against the bacteria that have sensitivity to it. Due to the inclusion in the drug beta-lactamase inhibitor (clavulanic acid) may be appointed agent, and infections that are resistant to the action of amoxicillin. Amoxicillin combined with clavulanic acid is active against: Streptococcus pneumonie, Str. bovis, Str. pyogenes, Listeria spp., Staphylococcus aureus, S. epidermidis, Enterococcus spp. (Gram-positive aerobic bacteria), Moraxella catarrhalis, N. meningitidis, H. influenzae, E. coli, Klebsiella spp., Proteus spp., N. gonorrhoeae, Pasteurella multocida (gram-negative aerobic microorganisms), as well as against anaerobic infektantov (Bacteroides spp., Peptococcus spp., Clostridium spp., Actinomyces israelii, Peptostreptococcus spp.).
In general, the pharmacokinetic parameters of amoxicillin and clavulanic acid are similar in the combined use, so do not have a reciprocal effect on the pharmacokinetic properties of each individual substance. After receiving both domestic ingredients are absorbed well. Their maximum plasma concentrations are reached after about 60 minutes. The use of amoxiclav with meals does not affect the absorption of clavulanic acid and amoxicillin. The half-life of clavulanic acid for 60-70 minutes for amoxicillin - 78 minutes. Both substances penetrate into the tissues and body fluids easily, especially accumulate in the maxillary sinus secretions, lungs, middle ear cavity, peritoneal and pleural fluids, ovaries and uterus. When meningitis amoxiclav components penetrate the blood-brain barrier. Penetrate well through the placental barrier and are defined in trace amounts in breast milk.
When bolus amoxiclav at a dosage of 1.2 g maximum observed plasma concentration of clavulanic acid 28.5 mg / L, amoxicillin - 105.4 mg / ml. After 60 minutes, determined by the peak concentration of these substances in body fluids. Clavulanic acid and amoxicillin, and bind to plasma proteins, respectively, in 22-30% and 17-20%.
Clavulanic acid is subjected to intensive metabolism in the liver tissue. We derive in part from the exhaled air and feces, mostly - the kidneys. Amoxicillin is largely unchanged with urine.
Indications for use:
· Acute and chronic sinusitis;
· Retropharyngeal abscess;
· Otitis media;
· Pneumonia;
· Chronic bronchitis;
· Urinary tract infections;
· Odontogenic infections, including periodontitis;
· Gynecological infections;
· Gonorrhea (including those caused by the gonococcus, which produce beta-lactamase;
· Infections of the skin and soft tissue (including wound infections);
· Chancroid;
· Bone and joint infections;
· Prevention of septic complications in surgical interventions on the organs of the pelvis, abdomen, kidneys, heart, bile ducts;
· Treatment of mixed infections caused by gram-positive and gram-negative microorganisms, as well as anaerobic pathogens (infection of the biliary tract, ENT infections, and postoperative abdominal infection, aspiration pneumonia, abscess of the breast);
· Oral and Maxillofacial Surgery;
· Orthopedic Practice.
Method of application:
Tablets Amoxiclav
The tablets are dissolved before use in half a glass of water (not less than 100 ml). The resulting suspension was thoroughly mixed, or chew tablets before swallowing. Appointed inside for children weighing 40 kg or more, as well as adults. The average daily dose is 375 mg (1 tablet) every 8 hours (3 p / day) or 625 mg (1 tablet) 2-3 p / day (depending on the severity of infection).
Tablets Amoxiclav 2X
Appointed only for adult patients with severe respiratory disease, or severe infections of 1000 mg (1 tablet) twice a day.
The maximum daily dose for adults is 6000 mg of amoxicillin. The maximum daily dose of clavulanic acid in the form of potassium salt - 600 mg.
In the pediatric
Children from the first days of life until the age of three months prescribed in doses of 30 mg / kg / day (based on amoxicillin), the daily dose is divided equally, to take at regular intervals.
Amoxiclav is prescribed from the age of 3 months or more or weighing less than 40 kg, 25 mg / kg / day (divided into two injection every 12 hours) or 20 mg / kg / day (divided into 3 injections every 8 hours) - with infectious diseases of moderate severity. In severe infections Amoxiclav use of 45 mg / kg / day (dose divided into 2 doses every 12 hours) or 40 mg / kg / day (divided in 3 doses every 8 hours).
The maximum daily dosage for children is 45 mg per 1 kg of body weight. The maximum daily dose of clavulanic acid in the form of potassium salt - 10 mg per 1 kg of body weight.
In the case of infections of moderate daily dose - 25 mg / kg every 12 hours (based on amoxicillin.)
In the lower respiratory tract infections, sinusitis, otitis media, and other severe infections Amoxiclav administered to children at the rate of 45 mg / kg / day of amoxicillin every 12 hours.
Patients with renal insufficiency
In case of insufficiency of the kidneys to the level of creatinine clearance 10 mL / min or less amoxiclav dosage adjust or increase the interval between drug intake. If anuria period between doses may be 48 hours.
When creatinine clearance 80 mL / min and a gap between the intake amoxiclav is 8 hours, clearance of 80-50 ml / min - 8:00, with clearance of 50-10 ml / min - 12 hours, clearance 10 mL / min and less than 0 24 hours.
Amoxiclav - Suspension
The exact dose of amoxiclav suspension for pediatric patients is calculated only on the basis of body weight.
Before preparing the suspension of the drug vial was shaken well before the separation of the powder particles from the bottom and walls of the vessel. The vial for 2 doses added to 86 ml of water after each addition of water the bottle thoroughly shaken. A measuring spoon for receiving amoxiclav suspension contains 5 ml of the drug, half - 2.5 ml; ¾ - 3,75 ml.
Amoxiclav for parenteral use
Amoxiclav 30 mg for intravenous administration contains 5 mg of clavulanic acid and 25 mg of amoxicillin. Preparation of solutions for intravenous administration amoxiclav: the contents of the vial is dissolved in water for injection (for amoxiclav 600 mg - 10 mL of water for amoxiclav 1.2 g - 20 mL of water). The resulting solution should be administered intravenously slowly over 3-4 minutes. If the drug is administered as an intravenous infusion, then 600 mg amoxiclav was dissolved in 10 ml water for injection, and then added to the infusion solution (50 mL). Amoxiclav - 1.2 g dissolved in 20 mL of sterile water and added to 100 ml of infusion solution. Intravenous infusion is carried out for 30-40 minutes. Intravenous amoxiclav should begin no more than 20 minutes after preparation of the solution. Do not freeze the solution is allowed amoxiclav.
Assign children over 12 years old (or weighing 40 kg and over) and adults (intravenously) at 1.2 g every 8 hours. In pediatrics - children from 3 months to 12 years - 30 mg / kg every 8 hours. In severe disease the drug is administered every 6 hours (for children under 3 months - 30 mg / kg every 8 hours). Children first days of life, including premature infants, Amoxiclav administered 30 mg / kg every 12 hours. After a therapeutic effect for bolus amoxiclav can switch to oral intake. Amoxiclav treatment of children and adults continue for 14 days.
The application for the prevention of septic complications before surgery
Prescribed prior to anesthesia, 1.2 g intravenously: in the case of brief interventions - once, when prolonged (more than 60 minutes) to the additional introduction of the solution - 1.2 g (maximum - up to 4 times a day). At high risk for infectious complications continue to introduce amoxiclav intravenously or orally in the postoperative period, especially during the operation were obvious signs of infection (in this case continue to intravenous administration after surgery).
In renal failure
In renal insufficiency, the dose for intravenous injection is calculated from the creatinine clearance: the clearance of 30 ml / min and a dosage is not correct, with clearance of 10-30 ml / min, therapy begins with the intravenous administration of 1.2 g, and then allocate 600 mg every 12 h and clearance of 10 ml / min or less treated with intravenous administration of 1.2 g, then 600 mg administered intravenously with an interval of 24 h of renal failure in children as well spend the correction dose. If the patient hemodialysis, approximately 85% of the money out of the body. After dialysis Amoxiclav administered at a dosage of 600 mg intravenously. Peritoneal dialysis does not take the drug, and therefore dosage adjustment is needed.
Amoxiclav Kviktab
The tablets are dissolved before use in half a glass of water (not less than 100 ml). The resulting suspension was thoroughly mixed, or chew the tablet before swallowing. Amoxiclav Kviktab best taken at the beginning of a meal.
For children weighing 40 kg or more, as well as for adult daily intake Amoxiclav Kviktab - 500mg of amoxicillin and clavulanic acid 125 mg (1 tablet) 2-3 p / day every 8-12 hours, or 875 mg/125 mg (1 tablet) 2 p / day every 12 hours. The usual dosing regimen for infections of mild to moderate severity - 500 mg/125 mg (1 tablet) 2 p / day every 12 hours. For severe disease - 875 mg/125 mg 2 p / day every 12 hours. Duration of treatment depends on the evidence that the individual is determined by a physician, but should not exceed 2 weeks.
In renal failure
Excretion of clavulanic acid and amoxicillin in renal failure, delay, and therefore reduce the dosage depending on the severity of functional disorders. You can increase the interval between doses of the drug. In mild renal impairment with creatinine clearance 0,166-0,5 ml / s Amoxiclav Kviktab appoint 500 mg/125 mg (1 tablet) 2 p / day every 12 hours. When clearance of less than 0.166 mL / s using a dose of 500 mg/125 mg (1 tablet) 1 p / day (every 24 hours).
Amoxiclav side effects:
Side effects are usually temporary and mild.
Part of the digestive system: nausea (3%), diarrhea (4.1%), dyspepsia (1.6%) and vomiting (1.8%), rarely - flatulence, anorexia, gastritis, glossitis, enterocolitis, stomatitis or change color language. During or after discontinuation of therapy amoxiclav may develop pseudomembranous colitis caused by Clostridium difficile toxin formation.
For the skin: angioedema, rash, urticaria, rarely - erythema multiforme, exfoliative dermatitis, Stevens - Johnson, toxic epidermal necrolysis.
The nervous system: seldom - agitation, anxiety, headache, dizziness, inappropriate behavior, insomnia, seizures, confusion, hyperactivity.
Blood system: thrombocytopenia, anemia (including cases of hemolytic anemia), leukopenia, eosinophilia, agranulocytosis.
Hepatobiliary disorders: possible increase in the parameters of liver function tests, including an increase in activity (asymptomatic) AlAT and / or AST, alkaline phosphatase and serum bilirubin levels. Liver function abnormalities typically occur in elderly patients or patients who are prescribed long-term therapy the drug. Hepatitis and cholestatic jaundice have been developing quite rare. Signs and symptoms usually occur during treatment or immediately after the completion of the course, but sometimes it may not be apparent for several weeks after therapy.
Urinary system: haematuria and interstitial nephritis (rare).
Other: vulvovaginal candidiasis (1%) and fever taking a long time can cause oral candidiasis.
· Hepatitis and cholestatic jaundice, triggered by the reception of antibiotics penicillin group in history;
· Individual sensitivity to clavulanic acid and amoxicillin, as well as other components amoxiclav or penicillin drugs.
There is no information about the teratogenic effect of active ingredients amoxiclav, so on the strict drug may be administered during pregnancy and breastfeeding.
Interactions with other drugs:
Amoxiclav for intravenous use is compatible with water for injection, lactate Ringer's solution, isotonic sodium chloride solution, a solution of potassium chloride. Less stable Amoxiclav in media containing glucose or dextran. Do not mix the drug with other drugs for parenteral administration in a single volume.
Excess doses is unlikely, but receiving a large dose of amoxiclav may cause the following symptoms: insomnia, agitation, dizziness, rarely - seizures. In overdose possible to carry out hemodialysis treatment - symptomatic.
In a dry place. Store at 25 ° C.

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