Azitromycin tab. 500 mg #3 without prescription - online pharmacy

Azitromycin tab. 500 mg #3

Azitromycin tab. 500 mg #3
Manufactured by: India
Product Code: 2294
$7.83

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You can buy Azitromycin tab. 500 mg #3 here.

 

Mode of action:
Broad-spectrum antibiotic. Antibiotic-azalides, representative of a new subgroup of macrolide antibiotics. When you create inflammation in high concentrations has a bactericidal effect.
To azithromycin susceptible gram-positive cocci: Streptococcus pneumoniae, St. pyogenes, St. agalactiae, Streptococcus groups CF and G, Staphylococcus aureus, St. viridans; gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, B. parapertussis, Legionella pneumophila, H. ducrei, Campylobacter jejuni, Neisseria gonorrhoeae and Gardnerella vaginalis; some anaerobic bacteria: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp; and Chlamydia trachomatis, Mycoplasma pneumoniae, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdoferi. Azithromycin is not active against Gram-positive bacteria resistant to erythromycin.
 
Pharmacokinetics.
Suction. Azithromycin is rapidly absorbed from the gastrointestinal tract, due to its stability in acid medium and lipophilicity. After oral administration of 500 mg azithromycin azithromycin maximum concentration in plasma is reached after 2.5 -2.96 h and 0.4 mg / l. Bioavailability is 37%.
 
Distribution.
Azithromycin is well into the respiratory tract, organs and tissues of the urogenital tract (in particular, in the prostate gland), the skin and soft tissues. High concentrations in the tissues (10-50 times higher than in blood plasma) and long half-life of azithromycin due to low binding to plasma proteins, and its ability to penetrate into eukaryotic cells and concentrate in an environment with low pH, environmental lysosomes. This, in turn, defines a large apparent volume of distribution (31.1 L / kg) and high plasma clearance. The ability of azithromycin to accumulate mainly in lysosomes is particularly important for the elimination of intracellular pathogens. Proved that phagocytes deliver azithromycin to the sites of infection, where it is released in the process of phagocytosis. The concentration of azithromycin in the foci of infection was significantly higher than in healthy tissues (average 24-34%) and correlated with the degree of inflammatory edema. Despite the high concentration in phagocytes, azithromycin did not significantly affect their function.
Azithromycin remains in bactericidal concentrations of inflammation within 5-7 days after the last dose, which allowed the development of short (3-day and 5-day) courses of treatment.
 
Excretion.
Excretion of azithromycin from plasma takes place in two stages: the half-life of 14-20 hours in the range of 8 to 24 hours after dosing and 41 hours - in the range of 24 to 72 hours, which allows the use of the drug 1 time / day.
 
 
Indications for use:
Infectious diseases caused by pathogens susceptible to the drug: infections of the upper respiratory tract and upper respiratory tract - tonsillitis, sinusitis (inflammation of the sinuses), tonsillitis (inflammation of the tonsils / glands /), otitis media (inflammation of the middle ear), scarlet fever, infections lower respiratory tract infections - bacterial and atypical pneumonia (inflammation of the lungs), bronchitis (inflammation of the bronchial tubes), infections of skin and soft tissue, erysipelas, impetigo (a superficial pustular skin lesions with the formation of purulent crusts), secondarily infected dermatitis (skin disease), infections of the urinary ways - and negonoreyny gonorrheal urethritis (inflammation of the urethra) and / or cervicitis (inflammation of the cervix), Lyme disease (borreliosis - an infectious disease caused by the spirochete Borrelia).
 
 
How to use:
Before the patient is given the drug is desirable to determine sensitivity to microorganisms that caused the disease in this patient. Azithromycin should always be taken one hour before or 2 hours after meals. The drug is taken one time a day.
Adults with infections of the upper and lower respiratory tract infections, skin and soft tissue appoint 0.5 g on day 1, followed by 0.25 g of 2-to 5-day or 0.5 g daily within 3 days (course dose of 1.5 g).
In acute infections of the urogenital (urinary) tract designate single 1 g (2 tablets of 0.5 g).
When Lyme disease (borreliosis) for the treatment of the first stage (erythemamigrans) appoint 1 g (2 tablets of 0.5 g) in 1-day and 0.5 g daily from 2 to 5 days (course dose 3 g).
Prescribe the drug to children to take the weight of the body. Children weighing more than 10 kg at the rate of: 1 and day - 10 mg / kg body weight for the next 4 days - 5 mg / kg. Possible 3-day course of treatment, in which case a single dose of 10 mg / kg. (Course dose of 30 mg / kg body weight).
Recommended break in 2 hours between azithromycin and antacid (reducing acidity) drugs at their simultaneous appointment.
 
 
Side effects:
Nausea, diarrhea, abdominal pain, at least - vomiting, and flatulence (accumulation of gas in the intestines). Possible transient (transient) increase in liver enzymes. Very rarely - a skin rash.
 
 
Contraindications:
Hypersensitivity to macrolide antibiotics. Care should be taken with a drug to patients with severely impaired liver and kidney function. During pregnancy and lactation is not prescribed azithromycin, except for the cases when the benefits of the drug exceeds the risks. The drug should be used with caution in patients with an indication of an allergic reaction in history (history).
 
Drug Interactions.
Enhances the effect of ergot alkaloids, dihydroergotamine. Tetracycline and chloramphenicol - increase the effect (synergism), lincosamides - lowering effect. Antacids, ethanol, food slow down and reduce the absorption. Slows excretion, increased serum concentrations and enhances the toxicity of cycloserine, indirect anticoagulants, methylprednisolone and felodipine. Inhibiting microsomal oxidation in hepatocytes, lengthens T1 / 2, slow excretion, improves concentration and toxicity of carbamazepine, ergot alkaloids, valproic acid, geksobarbital, phenytoin, disopyramide, bromocriptine, theophylline and other xanthine derivatives, oral hypoglycemic agents. Incompatible with heparin.
 
Precautions.
Observe break 2 hours, while the use of antacids. Use caution when expressed by human liver, kidney, cardiac arrhythmias (ventricular arrhythmias and prolongation QT). After discontinuation of treatment of hypersensitivity reactions in some patients may persist, which requires specific therapy under medical supervision.
 
 
Product:
Pills to 0,125 g of azithromycin dihydrate in a package of 6 pieces, 0.5 grams of pills azitromiiina dihydrate in a package of three pieces; capsules of 0.5 g of azithromycin dihydrate in a package of 6 pieces; syrup in vials forte syrup in bottles.
Azivok: capsules 250 mg.
Sumamed: tablets 125 mg and 500 mg capsules 250 mg powder for oral suspension 100 mg / 5 ml and 200 mg / 5 ml in 20 ml vials.
 
 
 
Storage:
In a dry, dark place at a temperature of 15-25 ° C. Keep out of reach of children.
Shelf life: 2 years. Do not use after the expiration date.
Available on prescription.
 
 
 
Ingredients:
9-deoxy-9a-aza-9a-methyl-9a-homoerythromycin A.
The white crystalline powder.

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