Azitromycin-Zdorovie tab. 250 mg #6

Azitromycin-Zdorovie tab. 250 mg #6
Manufactured by: Ukraine
Product Code: 8200

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Pharmacological properties.
Pharmacodynamics. Broad-spectrum antibiotic, belongs to the subgroup of macrolide antibiotics - azalidov. At high concentrations possible bactericidal effect.
Azithromycin activity against aerobic gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus spp. Groups C, F and G, Streptococcus viridans, Staphylococcus aureus; aerobic gram-negative bacteria: Haemophilus ducreyi, Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Legionella pneumophila, Campilobacter jejuni, Helicobacter pylori, Neisseria gonorrhoea, Gardnerella vaginalis; anaerobic bacteria: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp.
It is also relatively active Chlamydia pneumoniae, Chlamydia trachomatis, Mycroplasma pneumoniae, Ureaplasma urealyticum, Borellia burgdorferi.
Suction: azithromycin is rapidly absorbed from the gastrointestinal tract. After oral administration of 500 mg of azithromycin maximum concentration in plasma levels reached after 2,5-2,96 hour and 0.4 mg / l. Bioavailability is 37%.
Distribution: azithromycin well into the respiratory tract, organs and tissues of the urogenital tract (in particular, in the prostate gland), the skin and soft tissues. High concentrations in the tissues and long half-life of azithromycin due to low binding to plasma proteins.
Azithromycin remains in bactericidal concentrations of inflammation for 5-7 days after the last dose.
Metabolism is metabolized in the liver, loss of activity. The use of food significantly alter the pharmacokinetics.
Vivedennya 50% vivoditsya bile unchanged, 6% - in the urine.
Infectious-inflammatory diseases caused by pathogens susceptible to the drug:
upper respiratory tract infection (sore throat, sinusitis, tonsillitis, otitis media);
scarlet fever;
respiratory tract infections (bacterial and atypical pneumonia, bronchitis);
skin and soft tissues (erysipelas, impetigo, secondarily infected
urogenital tract infection (uncomplicated urethritis and / or cervicitis);
Lyme disease (borelioz) in the treatment of early stages (erythema migrans);
gastric and duodenal ulcers associated with Helicobacter
Dosage and administration.
Inside for 1 hour before or 2 hours after meals.
Adults with infections of the upper and lower respiratory tract infections, skin and soft tissue appoint 500 mg / day for 3 days (course dose - 1.5 g). Children weighing 15 kg administered at 10 mg / kg of body weight one time per day for 3 days. Course dose - 30 mg / kg.
In uncomplicated urethritis and / or cervicitis adults designate a one-time 1 year
When Lyme disease (borelioze) in adults for the treatment of early stages (erythema migrans) administered 1 g on day 1 and 500 mg each day from 2 to 5 days (course dose - 3 g). Children weighing 15 kg - the first day in a dose of 20 mg / kg body weight, from 2 to 5 days - 10 mg / kg of body weight one time per day for 5 days.
In diseases of the stomach and duodenal ulcers associated with Helicobacter pylori, adults appoint 1 g per day for 3 days in a combination therapy.
Children weighing more than 15 kg administered at 10 mg / kg of body weight one time per day for 3 days. Course dose - 30 mg / kg. Children over 12 years: at doses for adults.
On failure to receive one dose missed dose should be taken as soon as possible. And the next - with an interval of 24 hours
Side effect.
On the part of the digestive system: nausea, diarrhea, abdominal pain, rarely - vomiting, flatulence, transient increase in liver enzymes.
Can skin rash, cholestatic jaundice, headache, drowsiness, jade, vaginitis, neutropenia or neutrophilia, photosensitivity, eosinophilia. The children - agitation, insomnia, conjunctivitis, hyperkinesia.
Hypersensitivity to macrolide antibiotics.
Nausea, vomiting, diarrhea, temporary loss of hearing. Treatment is symptomatic.
Features of the application.
With care prescribe the drug to patients with impaired liver and / or kidneys.
During pregnancy and lactation drug is prescribed only if the expected benefit to the mother outweighs the potential risk to the fetus or child.
This dosage form (capsules) for use in children under the age of 5 years is not shown.
Interactions with other drugs.
Antacids containing magnesium or aluminum hydroxide, reduce the absorption of azithromycin-Health. Therefore it is recommended to adhere to a break of at least 2 hours between doses of azithromycin and antacids.
Azithromycin is not associated with the cytochrome P450 enzyme complex, and therefore does not interact with oral anticoagulants, carbamazepine, phenytoin, digoxin, cyclosporine, ergotamine, but caution should be followed when they are applied simultaneously.
Shelf life.
Store in a dry, dark place at a temperature from 15 ° C to 25 ° C. Keep out of reach of children.
Shelf life - 2 years.
Conditions of supply.

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