Sedalgin Plus tablets #10

Sedalgin Plus  tablets #10
Manufactured by: Bulgary
Product Code: 26528
$7.50

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You can buy Sedalgin Plus tablets #10 here.

 

Pharmacological properties.
Pharmacodynamics.
Combined preparation with a clear analgesic and antipyretic action and a less pronounced anti-inflammatory activity and the sedative effect. In combination increases the analgesic effect of individual components to include additional mechanisms, on the one hand, and on the other - reduced side effects and the possibility of drug dependence by the use of lower doses of each component of the dosage form.
Included in the neo-sedalgin paracetamol and metamizol in the main exhibit analgesic and antipyretic effect associated with suppression of COX in the periphery and in the brain and stimulation of beta-endorphins, inhibition of synthesis of endogenous algogeny, lower the threshold of excitability in the thalamus and the conduct of pain exteroceptive and interoceptive- impulses in the central nervous system, effects on the hypothalamus and the formation of endogenous pyrogens. Metamizole reveals some antispasmodic effects on smooth muscle biliary and urinary tracts, and the muscles of the uterus.
In small doses, phenobarbital has a sedative effect in the main. It potentiates the analgesic activity of the components.
Caffeine reduces the headache due to cerebral vasoconstriction and reduce intracranial pressure. Its stimulating effect overcomes the sedative and depressive effects of other components. It facilitates the penetration of analgesics krovomozkovy a barrier and prevents collapse, exciting vasomotor center.
Codeine phosphate has a central analgesic and sedative effect, and potentiates the analgesic effect of paracetamol and metamizol. Has a clear antitussive effect.
 
 
Pharmacokinetics.
The individual components of the combination of fast and well absorbed from the gastrointestinal tract and have a relatively fast metabolism. Slightly bound to plasma proteins. Undergo relatively rapid metabolism, mainly in the liver, and caffeine, phenobarbital, and to some extent play the role of metamizole inductors associated with the cytochrome P450 enzyme systems, symbionts, and drugs may affect the biotransformation and toxicity of several drugs. Derived mainly from the urine.
After application of paracetamol into the maximum plasma concentrations are up to 2 hours. Metabolized primarily in the liver to form glucuronides and sulfate compounds.
Metamizole is rapidly absorbed, reaching maximum plasma levels of 30 - 90 minutes.
Phenobarbital, caffeine and metamizol penetrate into the bloodstream of the fetus and excreted in breast milk. The half-life of codeine is 3 - 4 hours, caffeine - 3 - 6 hours, paracetamol - 1.5 - 3 hours, metamizol - up to 10 hours, phenobarbital - 90 - 100 hours.
 
Indications for use
 
. Short-term and symptomatic treatment of pain of various origins, which can not be alone.
The main and toothache, migraine.
Post-traumatic, post-operative pain and pain after burns.
Neuralgia and neuritis, acute pain in joints and muscles.
 
Dosage and administration
 
. Inside during the meal, washed down with water.
The recommended daily dose for adults and children over 14 years - 1 tablet 3-4 times daily.
The maximum single dose - 2 tablets, the maximum daily dose - 6 tablets.
The maximum duration of treatment - 3 days.
 
Side effects
 
The most common side effects are temporary and disappear after cessation of treatment. Some patients may be manifestations of increased risk of anaphylaxis and agranulocytosis, which may at any time during treatment and are independent of the daily dose
allergic reactions such as rash, itching, hives, bronchospasm provocation, dyspnea
from the digestive tract - dry mouth, epigastric pain, anorexia, nausea, vomiting, constipation or diarrhea, increase in transaminases;
of the nervous system - drowsiness, fatigue, impaired coordination, tremors, restlessness, irritability, prolonged uncontrolled use of high doses - addiction and drug dependence;
of the cardiovascular system - palpitation, hypotension, tachycardia, extrasystoles
of the genitourinary system - long-term use at high doses may be manifestations of nephrotoxicity (interstitial nephritis, renal development nedostatnsti)
of the hemopoietic system - in rare cases - hemolytic anemia, and thrombocytopenia.
 
Contraindications
 
Sedalgin-neo is contraindicated in pregnancy and breastfeeding
hypersensitivity to any component of the drug
hypersensitivity (anaphylaxis or agranulocytosis), a history associated with the use of metamizole or other drug pirazolonovogo
bronchial asthma ("ASA");
hemorrhagic diathesis, anemia, in the presence of anamnestic data of agranulocytosis
congenital deficiency glokozo-6-phosphate dehydrogenase;
porphyria liver.
The drug is not prescribed for pregnant women and during breast-feeding infants, given the combination of phenobarbital, codeine phosphate and caffeine, which are dangerous for the embryo, fetus and newborn. Most of the components goes into the milk. Caffeine can cause neonatal reflux effect.
Most of the components acting on the central nervous system, alters psychomotor reaction, so do not take medication while operating motor vehicles and the performance of work on machines that require attention.
 
Interaction with other medicinal products
 
The components of the neo-sedalgin affect the metabolism of many drugs, so you should avoid the simultaneous use of other drugs.
Metamizole lowers the activity of coumarin anticoagulants, reduces serum levels of cyclosporine. Tricyclic antidepressants, oral contraceptives and allopurinol potentiate its action as a result of enzyme inhibition and slowing of its biotransformation.
The simultaneous use metamizol with chloramphenicol and other facilities that affect the bone marrow, increases the myelotoxic action.
Paracetamol, while the use aminofenazonom may increase the effects of both drugs and increase their toxicity.
Paracetamol increases the effect of coumarin anticoagulants. As an inducer of microsomal enzymes, paracetamol may reduce the effects of drugs undergoing intensive biotransformation in the liver. Inducing glyukuronidnyh and sulfate conjugation, birth control pills weaken its effect. Likewise, rifampicin reduces its analgesic effect. Cimetidine reduces its toxicity and enhances analgesia. Paracetamol increases the decomposition of chloramphenicol by competitive suppression of its metabolism and leads to an increased risk of myelotoxicity.
The simultaneous use of hepatotoxic drugs and alcohol increases the risk of renal dysfunction increase hepatotoxicity and increased education of hepatotoxic metabolite of paracetamol due to enzyme induction.
Codeine increases the inhibitory effect on the central nervous system of alcohol, barbiturates, beznzodiazepiniv, hypnotics and sedatives. The use of MAO inhibitors or tricyclic antidepressants with codeine may result in a mutually reinforcing effects. Concomitant use of anticholinergic drugs and codeine can cause paralysis of the bowel.
Caffeine reduces the effect of sleeping pills, and enhances the effects of NSAIDs.
Phenobarbital lowers serum levels of salicylate and its anticoagulant activity, as the enzyme inducer accelerates the metabolism of griseofulvin, quinidine, doxycycline, estrogens, sometimes - phenytoin, carbamazepine. Its inhibitory effect is enhanced when combined with alcohol, tricyclic antidepressants, phenothiazines, narcotic analgesics. Sodium valproate and valproic acid inhibit the metabolism of phenobarbital.
 
Overdose
 
With an overdose of the drug may attack some of the following symptoms: central nervous system depression, which manifests itself dizziness, drowsiness, slow reactions, respiratory depression, a significant weakness until he lost consciousness, slowing heart rate, lowering blood pressure.
Emergency measures in case of symptoms of overdose are the immediate cessation of the drug, the removal of stomach contents (to induce vomiting, stomach lavage), the purpose of the use of activated charcoal and symptomatic treatment. Before removing the drug from the body to maintain adequate ventilation and stable hemodynamics.
 
Features of the application
 
. Treatment with immediate stop when symptoms of anaphylaxis (a sudden occurrence of a severe allergic reaction, which is characterized by skin rash, shortness of breath, complaints of violations of the digestive tract or cardiovascular system) and agranulocytosis (severe neutropenia, fever, sepsis, and other manifestations of infection) .
With more frequent and prolonged use of neo-sedalgin necessary to control the blood picture and liver function and kidney function.
In the treatment of drug benefits must clearly exceed the risks, otherwise it should discuss alternative treatments.
Do not use the neo-Sedalgin patients who have previously been observed manifestations of hypersensitivity to Metamizole. Should be avoided in patients with gastric ulcer in active stage and in severe renal and hepatic failure.
Due to lower tolerance to alcohol, its use should be avoided during treatment.
Long-term treatment of neo-sedalgin can lead to dependence on codeine, which is part of the drug.
The drug is not indicated for children under 14 years of age.
use extreme caution in elderly patients, despite an increase in the frequency of symptoms of intoxication.
The composition of the drug included wheat starch, and the drug is not used sick gluten enteropathy (congenital disease of the small intestine, which is characterized by manifestations of diarrhea in the application of wheat products).
Sodium metabisulfite, which is a subsidiary of drug substance, can cause allergic reactions of the type, including anaphylaxis in susceptible patients.
The metabolites of metamizol can change the color of urine to red, it does not matter for the clinic.
 
Terms and Conditions of storage
and storage conditions.
Store in a dry, dark place at temperatures above 25 C.
Keep out of reach of children!
Do not use after expiry date.
Shelf Life - 3 years.
 
Methods of struggle against headache are really various and depend from many causes of original pains and other factors.
Now Sedalgin  is the most popular, well-known and a certified method. It seems that it’s a trivial tablet. But as a matter of fact Sedalgin is a strong pill.
Today it’s a big list of analgesic preparations at the market, among of them there’re monocomponent and combined tablets. Combined pills have the row of incontestable advantages. Sedalgin is also combined preparation, it have some working substances in a little amount. It decreases probability of side effects which is a cause of effects from using therapeutic doses of analgetics and nonsteroidal antiphlogistic preparations. In the second place Sedalgin has a right combination of the components which is increasing potential influence. Caffeine and codeine amplify the analgesic action of metamizole and paracetamol. And also caffeine decrease the sedative effect of phenobarbital and codeine. So combined preparations such as Sedalgin reach an optimal therapeutic effect.
Sedalgin is an improved view of Sedalgin. Sedalgin is preparation which consist of analgin, paracetamol, caffeine, phenobarbital and codeine. Combining in the preparation some analgetics with other components is increasing analgesic activity on the one hand, and it lets decrease risk of appearance of medicinal dependence on the other hand
Due to the consistency of Sedalgin-Neo we could say that preparation is an universal analgetic. For example metamizole and paracetamol influence at the peripheral nervous system. Caffeine and phenobarbital with codeine influence on central nervous system.
In case of using the preparation more than 1 week it’s necessary to control peripheral blood and functions of condition your liver. Sedalgin could change the result of analyses on doping control for sportments. It makes difficulties for detecting diagnosis in case of abdominal emergencies. Sedalgin could bring on allergic reaction for people who suffers from atopy bronchial asthma, pollinosis.
 

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